In the sports nutrition market, Selective androgen receptor modulators (SARMs) have become hugely popular as a viable alternative to anabolic steroids. The fact that SARMS don’t result in common side effects of steroids such as gynecomastia, acne, and shrinking of testicles and targets the androgen receptors in ways where they are more beneficial says it all.
These non-steroidal and tissue-selective anabolic agents are considered by athletes across the globe as the next-generation muscle-builders to gain muscle mass, improve strength, and lose fat.
Medical Use Of SARMS
Selective Androgen Receptor Modulators have been used in the medical world for treating a wide range of health complications, mild and severe.
- Ostarine (also known as MK-2866 and Enobosarm) is medically used to treat muscle and bone. This Selective Androgen Receptor Modulator is also effective to reverse muscle sarcopenia in the elderly and is considered as the general treatment for andropause. Commonly used for treating osteoporosis, Ostraine is equally effective to treat cachexia in cancer patients.
- LGD-4033 (also known as Anabolicum and Ligandrol) is clinically indicated for cachexia, andropause, and muscle sarcopenia reversal in the elderly.
- S4 (also known as Andarine) is clinically indicated for treating benign prostatic hypertrophy, muscle wasting, and osteoporosis. This orally-active partial agonist for androgen receptors has the potential of competitively blocking binding of Dihydrotestosterone (DHT) to its prostate gland’s receptor targets and its partial agonist effects at androgen receptors prevent the health complications or side effects that can be associated with the anti-androgenic drugs traditionally used for treatment of benign prostatic hypertrophy.
- Testolone (also known as RAD140) is clinically indicated for treatment of severe health complications like breast cancer and muscle wasting.
Legality Of SARMS
Selective Androgen Receptor Modulators (SARMs) are research chemicals and legal in many countries of the world. It is important to note that a large chunk of SARMS are not scheduled or prescription drugs.
Under the Dietary Supplement Health and Education Act of 1994 (“DSHEA”) of the US Food and Drug Administration (FDA), SARMS cannot be sold as supplements or at supplement stores. In other words, SARMS are not legal as ingredients in any type of dietary supplement for sale in the United States. However, they are still very legal for research and medicinal purposes.
It can be made out from the statements that SARMS are absolutely legal for treating health complications such as muscle-wasting, osteoporosis, etc. under medical supervision but athletes and others may not enjoy the privilege of “legal immunity” of using these drugs when they use them for performance enhancements.
In 2008, the World Anti-Doping Agency (WADA) added SARMS to the list of prohibited substances means they are banned at-all-times for athletes covered under the WADA Code. This is primarily because though SARMS are not steroid drugs, they have the potential to produce the anabolic effect of anabolic androgenic steroids. Selective Androgen Receptor Modulators tend to work quite similarly to Testosterone but in a more specific and targeted way. This is done as SARMS get bind to the steroid receptor in only a specific tissue, such as muscle.
A big majority of fitness enthusiasts still make use of these performance enhancing drugs for losing body fat, gaining muscle mass, improving strength or performance, getting in good shape, and improving workout performances. It is no surprise that there have been over 30 Adverse Analytical Findings (AAF) reported for SARMs between 2012 and 2014 as per the WADA Anti-Doping Testing Figures. It was even reported in the media that Will Grier, the quarterback of the Florida Gators, allegedly tested positive for LGD-4033 however this claim was denied by the University of Florida.
Charlie Francis, the world famous athletics coach of Ben Johnson, once remarked that S4 and Ostraine were already in use at the Beijing Olympics of 2008. Francis also commented that SARMS were the “dope de jeur” at the 2009 Berlin world athletics championships. Francis had further remarked that Selective androgen receptor modulators have the ability to enhance the production and utilization of Testosterone and a pretty potential cocktail can be made if SARMS are stacked with Human growth hormone. It was and is these reasons and many more that SARMS have had almost became a household name in countries such as the United States, Australia, the United Kingdom, and Canada to name a few.